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Breast cancer multigene germline panel testing in mainstream oncology based on clinical-public health utility (cancer mortality benefit): ESMO Precision Oncology Working Group recommendations

2025-02-25

Abstract excerpt

<h4>Background</h4> With widening therapeutic indications, germline genetic testing is offered to an increasing proportion of patients with breast cancer (BC) via mainstream oncology services. However, the gene set tested varies widely from just BRCA1/BRCA2 through to ‘pan-cancer’ panels of near 100 genes. If a germline pathogenic variant (GPV) is detected, the BC proband and other family GPV-carriers may be offer...

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Literature Corpus work: a9ebdc93-998c-5609-b0e7-0bd90728b5b6
DOI: 10.1101/2025.02.25.25322856

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