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Pathogenic variants among females with breast cancer and a non-breast cancer reveal opportunities for cancer interception.

Breast cancer research and treatment - 1 Jul 2023

Bychkovsky Brittany L, Lo Min-Tzu, Yussuf Amal, Horton Carrie, Hemyari Parichehr, LaDuca Holly, Garber Judy E, Scheib Rochelle, Rana Huma Q

Abstract excerpt

PURPOSE: Herein, we report the frequency and distribution of germline pathogenic variants (PVs) among females with breast cancer (BC) and at least one other non-BC who underwent multi-gene panel testing (MGPT). Among females with PVs diagnosed first with BC or ovarian cancer (OC), we sought to enumerate the frequency of subsequent PV-associated cancers. METHODS: Females with BC and cancer of ≥ 1 other site...

Topics

Humans
Female
Breast Neoplasms
Genetic Predisposition to Disease
Genes, BRCA2
Ovarian Neoplasms
Protein Serine-Threonine Kinases
Germ-Line Mutation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36856935
DOI: 10.1007/s10549-023-06870-x
PMCID: PMC10224857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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