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Population-based germline breast cancer gene association studies and meta-analysis to inform wider mainstream testing.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Oct 2024

Rowlands C F, Allen S, Balmaña J, Domchek S M, Evans D G, Hanson H, Hoogerbrugge N, James P A, Nathanson K L, Robson M, Tischkowitz M, Foulkes W D, Turnbull C

Abstract excerpt

BACKGROUND: Germline genetic testing, previously restricted to familial and young-onset breast cancer, is now offered increasingly broadly to patients with 'population-type' breast cancer in mainstream oncology clinics, with wide variation in the genes included. PATIENTS AND METHODS: Weighted meta-analysis was carried out for three population-based case-control studies (BRIDGES, CARRIERS and UK Biobank)...

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PMID: 38986768
DOI: 10.1016/j.annonc.2024.07.244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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