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Article

Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer.

JAMA oncology - 1 Sept 2017

Couch Fergus J, Shimelis Hermela, Hu Chunling, Hart Steven N, Polley Eric C, Na Jie, Hallberg Emily, Moore Raymond, Thomas Abigail, Lilyquist Jenna, Feng Bingjian, McFarland Rachel, Pesaran Tina, Huether Robert, LaDuca Holly, Chao Elizabeth C, Goldgar David E, Dolinsky Jill S

Abstract excerpt

IMPORTANCE: Germline pathogenic variants in BRCA1 and BRCA2 predispose to an increased lifetime risk of breast cancer. However, the relevance of germline variants in other genes from multigene hereditary cancer testing panels is not well defined. OBJECTIVE: To determine the risks of breast cancer associated with germline variants in cancer predisposition genes. DESIGN, SETTING, AND PARTICIPANTS: A study...

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Source

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Identifiers

PMID: 28418444
DOI: 10.1001/jamaoncol.2017.0424
PMCID: PMC5599323

Genes

BRCA1
BRCA2
ATM
BARD1
BRIP1
CDH1
CHEK2
MLH1
NBN
PALB2
PMS2
PTEN
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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