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Multigenic panels in breast cancer: Clinical utility and management of patients with pathogenic variants other than BRCA1/2.

Critical reviews in oncology/hematology - 1 Sept 2024

Fabi Alessandra, Cortesi Laura, Duranti Simona, Cordisco Emanuela Lucci, Di Leone Alba, Terribile Daniela, Paris Ida, de Belvis Antonio Giulio, Orlandi Armando, Marazzi Fabio, Muratore Margherita, Garganese Giorgia, Fuso Paola, Paoletti Filippo, Dell'Aquila Rossella, Minucci Angelo, Scambia Giovanni, Franceschini Gianluca, Masetti Riccardo, Genuardi Maurizio

Abstract excerpt

Multigene panels can analyze high and moderate/intermediate penetrance genes that predispose to breast cancer (BC), providing an opportunity to identify at-risk individuals within affected families. However, considering the complexity of different pathogenic variants and correlated clinical manifestations, a multidisciplinary team is needed to effectively manage BC. A classification of pathogenic variants...

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PMID: 38977141
DOI: 10.1016/j.critrevonc.2024.104431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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