Article

Regulatory variants drive Hsp90’s effect on adaptation

2023-11-02

Abstract excerpt

<h4>Summary</h4> The essential, stress-responsive protein chaperone Hsp90 impacts adaptation from microbes to humans. Yet the molecular mechanisms involved remain unclear and are often presumed to be driven by variation in opening reading frames. Here, we identify over 1,000 natural genotype-to-phenotype associations governed by Hsp90 at single-nucleotide resolution in Saccharomyces cerevisiae . Strikingly, cis...

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Literature Corpus work: 2dfe4496-f823-554e-a3c8-9e741d693918
DOI: 10.1101/2023.10.30.564848

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