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Article

Class IA PI3K regulatory subunits: p110-independent roles and structures.

Biochemical Society transactions - 28 Aug 2020

Fox Millie, Mott Helen R, Owen Darerca

Abstract excerpt

The phosphatidylinositol 3-kinase (PI3K) pathway is a critical regulator of many cellular processes including cell survival, growth, proliferation and motility. Not surprisingly therefore, the PI3K pathway is one of the most frequently mutated pathways in human cancers. In addition to their canonical role as part of the PI3K holoenzyme, the class IA PI3K regulatory subunits undertake critical functions...

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Identifiers

PMID: 32677674
DOI: 10.1042/BST20190845
PMCID: PMC7458397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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