Article

Maturity Onset Diabetes of the Young (MODY) is not always monogenic: candidate genes involved in a Latino Population

2024-10-04

Abstract excerpt

<h4>Introduction</h4> MODY misdiagnosis remains widespread, existing remarkable variability within genetic variants across populations. While diagnostic tools are based on Caucasian cohorts, Whole Exome Sequencing (WES) studies are needed to identify new genes in non-Caucasians, as up to 77% of patients do not harbor variants of significance in MODY-known genes. In Latino populations, no WES studies have addressed...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e2b93715-2a5b-5053-9293-cb797a0281f2
DOI: 10.1101/2024.10.02.24314794

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Maturity Onset Diabetes of the Young (MODY) is not always monogenic: candidate genes involved in a Latino PopulationDOI 10.1101/2024.10.02.24314794Read

Genomic landscape of Mexican patients with maturity onset diabetes of the young: beyond mutations in MODY-known genes.Semantic proximity Read

Genetic Characterization of MODY in Iranian Families Using Multigenerational-Based Whole-Exome Sequencing Approach.Semantic proximity Read

Undiagnosed MODY: Time for Action.Semantic proximity Read

MODY is prevalent in later-onset diabetes, has potential for targeted therapy but is challenging to identifySemantic proximity Read

Maturity-onset diabetes of the young in a large Portuguese cohort.Semantic proximity Read

The Importance of Molecular Genetic Testing for Precision Diagnostics, Management, and Genetic Counseling in MODY Patients.Semantic proximity Read

Population Prevalence, Penetrance, and Mortality for Genetically Confirmed MODY.Semantic proximity Read

Population prevalence, penetrance, and mortality for genetically confirmed MODYSemantic proximity Read

Targeted sequencing identifies novel variants in common and rare MODY genesSemantic proximity Read

MODY Only Monogenic? A Narrative Review of the Novel Rare and Low-Penetrant Variants.Semantic proximity Read

Monogenic Childhood Diabetes: Dissecting Clinical Heterogeneity by Next-Generation Sequencing in Maturity-Onset Diabetes of the Young.Semantic proximity Read

Study of Thirteen Causal Genes in Turkish Patients with Clinically Suspected Maturity-Onset Diabetes of the Young (MODY) using a Targeted Next-Generation Sequencing PanelSemantic proximity Read