Article

A CNN model for predicting binding affinity changes between SARS-CoV-2 spike RBD variants and ACE2 homologues

2022-03-23

Abstract excerpt

<h4>ABSTRACT</h4> The cellular entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) involves the association of its receptor binding domain (RBD) with human angiotensin converting enzyme 2 (hACE2) as the first crucial step. Efficient and reliable prediction of RBD-hACE2 binding affinity changes upon amino acid substitutions can be valuable for public health surveillance and monitoring potential s...

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Literature Corpus work: a9920374-0d89-5fcf-8bd5-803496115247
DOI: 10.1101/2022.03.22.485413

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