Article
D3AI-Spike: A deep learning platform for predicting binding affinity between SARS-CoV-2 spike receptor binding domain with multiple amino acid mutations and human angiotensin-converting enzyme 2.
Computers in biology and medicine - 1 Dec 2022
Han Jiaxin, Liu Tingting, Zhang Xinben, Yang Yanqing, Shi Yulong, Li Jintian, Ma Minfei, Zhu Weiliang, Gong Likun, Xu Zhijian
Abstract excerpt
The number of SARS-CoV-2 spike Receptor Binding Domain (RBD) with multiple amino acid mutations is huge due to random mutations and combinatorial explosions, making it almost impossible to experimentally determine their binding affinities to human angiotensin-converting enzyme 2 (hACE2). Although computational prediction is an alternative way, there is still no online platform to predict the mutation effect of...
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