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Dynamics of binding ability prediction between spike protein and human ACE2 reveals the adaptive strategy of SARS-CoV-2 in humans.

Scientific reports - 4 Feb 2021

Xue Xia, Shi Jianxiang, Xu Hongen, Qin Yaping, Yang Zengguang, Feng Shuaisheng, Liu Danhua, Jian Liguo, Hua Linlin, Wang Yaohe, Zhang Qi, Huang Xueyong, Zhang Xiaoju, Li Xinxin, Chen Chunguang, Guo Jiancheng, Tang Wenxue, Liu Jianbo

Abstract excerpt

SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel coronavirus causing the COVID-19 pandemic in 2020. High adaptive plasticity on the spike protein of SASR-CoV-2 enables it to transmit across different host species. In the present study, we collected 2092 high-quality genome sequences of SARS-CoV-2 from 160 regions in over 50 countries and reconstructed their phylogeny. We also analyzed the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33542420
DOI: 10.1038/s41598-021-82938-2
PMCID: PMC7862608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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