Article
Clonal hematopoiesis and its impact on the aging osteo-hematopoietic niche.
Leukemia - 1 May 2024
Winter Susann, Götze Katharina S, Hecker Judith S, Metzeler Klaus H, Guezguez Borhane, Woods Kevin, Medyouf Hind, Schäffer Alexander, Schmitz Marc, Wehner Rebekka, Glauche Ingmar, Roeder Ingo, Rauner Martina, Hofbauer Lorenz C, Platzbecker Uwe
Abstract excerpt
Clonal hematopoiesis (CH) defines a premalignant state predominantly found in older persons that increases the risk of developing hematologic malignancies and age-related inflammatory diseases. However, the risk for malignant transformation or non-malignant disorders is variable and difficult to predict, and defining the clinical relevance of specific candidate driver mutations in individual carriers has proved...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.