Article

Structural models of the human iron exporter ferroportin in the inward- and outward- open states

2016-06-22

Abstract excerpt

Motivation Ferroportin (Fpn) is a membrane protein belonging to the Major Facilitator Superfamily of transporters. It is the only vertebrate iron exporter known so far. Several Fpn mutations lead to the so-called ‘ferroportin disease’ or type 4 haemochromatosis, characterized by two distinct iron accumulation phenotypes depending on whether the mutations affects the protein’s activity or its degradation pathway (1...

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Literature Corpus work: a9860da5-8129-5e7e-af47-e3c04ddd7939
DOI: 10.7287/peerj.preprints.2149v1

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