Article
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 2013
Shintre Chitra A, Pike Ashley C W, Li Qiuhong, Kim Jung-In, Barr Alastair J, Goubin Solenne, Shrestha Leela, Yang Jing, Berridge Georgina, Ross Jonathan, Stansfeld Phillip J, Sansom Mark S P, Edwards Aled M, Bountra Chas, Marsden Brian D, von Delft Frank, Bullock Alex N, Gileadi Opher, Burgess-Brown Nicola A, Carpenter Elisabeth P
Abstract excerpt
ABCB10 is one of the three ATP-binding cassette (ABC) transporters found in the inner membrane of mitochondria. In mammals ABCB10 is essential for erythropoiesis, and for protection of mitochondria against oxidative stress. ABCB10 is therefore a potential therapeutic target for diseases in which...
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