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Computational Studies of the Dynamics of the Human Iron Exporter Ferroportin: Insight into the Role of Crucial Residues Involved in Pathogenic Mutations in the Transport Mechanism

2026-08-11

Abstract excerpt

Ferroportin (FPN/SLC40A1), the only known human iron exporter, plays a key role in iron homeostasis through an alternating access mechanism involving inward-open, occluded, and outward-open conformations. Pathogenic FPN mutations cause Hereditary hemo-chromatosis type 4, an autosomal dominant iron overload disease characterized by ear-ly-onset anemia, hepatic fibrosis, and diabetes. This disease can be further cat...

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Literature Corpus work: fc57843e-8d0e-5039-b959-eb5cdc01e95b
DOI: 10.20944/preprints202608.0759.v1

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