Article

Structure and mechanism of a primate ferroportin

2020-03-05

Abstract excerpt

Ferroportin is the only cellular iron exporter in human and essential for iron homoeostasis. Mutations in ferroportin are associated with hemochromatosis or ferroportin diseases characterized by a paradoxical combination of anemia and abnormal accumulation of iron in cells. Ferroportin is also the target of hepcidin, which is a hormone that downregulates ferroportin activity. However, due to a lack of three-dimens...

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Literature Corpus work: 96ac4b2e-d2f1-5cd1-acdc-f3873d750540
DOI: 10.1101/2020.03.04.975748

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