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Article

Molecular model of the ferroportin intracellular gate and implications for the human iron transport cycle and hemochromatosis type 4A.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2019

Guellec Julie, Elbahnsi Ahmad, Tertre Marlene Le, Uguen Kevin, Gourlaouen Isabelle, Férec Claude, Ka Chandran, Callebaut Isabelle, Gac Gerald Le

Abstract excerpt

Ferroportin 1 (FPN1) is a major facilitator superfamily transporter that is essential for proper maintenance of human iron homeostasis at the systemic and cellular level. FPN1 dysfunction leads to the progressive accumulation of iron in reticuloendothelial cells, causing hemochromatosis type 4A (or ferroportin disease), an autosomal dominant disorder that displays large phenotypic heterogeneity. Although crystal...

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PMID: 31690120
DOI: 10.1096/fj.201901857R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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