Article
Molecular Deconvolution Platform to Establish Disease Mechanisms by Surveying GPCR Signaling.
Cell reports - 17 Jul 2018
Masuho Ikuo, Chavali Sreenivas, Muntean Brian S, Skamangas Nickolas K, Simonyan Kristina, Patil Dipak N, Kramer Grant M, Ozelius Laurie, Babu M Madan, Martemyanov Kirill A
Abstract excerpt
Despite the wealth of genetic information available, mechanisms underlying pathological effects of disease-associated mutations in components of G protein-coupled receptor (GPCR) signaling cascades remain elusive. In this study, we developed a scalable approach for the functional analysis of clinical variants in GPCR pathways along with a complete analytical framework. We applied the strategy to evaluate an...
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