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Π-Π Interactions Stabilize PeptoMicelle-Based Formulations of Pretomanid Derivatives Leading to Promising Therapy Against Tuberculosis in Zebrafish and Mouse Models

2022-03-11

Abstract excerpt

<h4>ABSTRACT</h4> Tuberculosis is the deadliest bacterial disease globally, threatening the lives of millions every year. New antibiotic therapies that can shorten the duration of treatment, improve cure rates, and impede the development of drug resistance are desperately needed. Here, we used polymeric micelles to encapsulate four second-generation derivatives of the antitubercular drug pretomanid that had previ...

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Literature Corpus work
a97061c9-6273-578e-b25a-d2c14120eb3c
DOI
10.1101/2022.03.10.483770
Open publication

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