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A novel C-4-modified isotetrone acts as a potent bio-enhancer to augment the activities of anti-tuberculosis drugs against Mycobacterium tuberculosis.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2024

Bokolia Naveen Prakash, Bag Kingshuk, Sarkar Biplab, Jhawar Ruchi, Chatterji Dipankar, Jayaraman Narayanaswamy, Ghosh Anirban

Abstract excerpt

Mycobacterium tuberculosis is a deadly pathogen that claims millions of lives every year. Current research focuses on finding new anti-tuberculosis drugs that are safe and effective, with lesser side effects and toxicity. One important approach is to identify bio-enhancers that can improve the effectiveness of anti-tuberculosis drugs, resulting in reduced doses and shortened treatment times. The present study...

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PMID: 39357126
DOI: 10.1016/j.tube.2024.102569

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