Glibenclamide, ATP and metformin increases the expression of human bile salt export pump ABCB11

Abstract excerpt

<h4>Background: </h4> Bile salt export pump (BSEP/ABCB11) is important in the maintenance of the enterohepatic circulation of bile acids and drugs. Drugs such as rifampicin and glibenclamide inhibit BSEP. Progressive familial intrahepatic cholestasis type-2, a lethal pediatric disease, some forms of intrahepatic cholestasis of pregnancy, and drug-induced cholestasis are associated with BSEP dysfunction.  <h4>Meth...

Topics

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• Biological Transport
• ATP Binding Cassette Transporter, Subfamily B, Member 11
• Bile Acids and Salts
• Cholestasis, Intrahepatic
• Disease Models, Animal
• Gene Expression Regulation
• Mutation
• Small Molecule Libraries

Identifiers and source

Literature Corpus work

a96a61cc-393d-5bad-a602-e7c578a6f777

DOI

10.12688/f1000research.26632.1