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Article

ABCB4: Insights from pathobiology into therapy.

Clinics and research in hepatology and gastroenterology - 1 Oct 2014

Falguières Thomas, Aït-Slimane Tounsia, Housset Chantal, Maurice Michèle

Abstract excerpt

Adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4), also called multidrug resistance 3 (MDR3), is a member of the ATP-binding cassette transporter superfamily, which is localized at the canalicular membrane of hepatocytes, and mediates the translocation of phosphatidylcholine into bile. Phosphatidylcholine secretion is crucial to ensure solubilization of cholesterol into mixed micelles...

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Identifiers

PMID: 24953525
DOI: 10.1016/j.clinre.2014.03.001

Genes

ABCB4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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ABCB4: Insights from pathobiology into therapy.PMID 24953525Read ↗

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ABCB4 disease: Many faces of one gene deficiency.Semantic proximity Read ↗

Functional characterization of ABCB4 mutations found in progressive familial intrahepatic cholestasis type 3.Semantic proximity Read ↗

MDR3 (ABCB4) defects: a paradigm for the genetics of adult cholestatic syndromes.Semantic proximity Read ↗

Canalicular ABC transporters and liver disease.Semantic proximity Read ↗

Liver diseases related to MDR3 (ABCB4) gene deficiency.Semantic proximity Read ↗

Case Report: A rare case of young adult progressive familial intrahepatic cholestasis-type 3 with a novel heterozygous pathogenic variant of ABCB4Semantic proximity Read ↗

A female of progressive familial intrahepatic cholestasis type 3 caused by heterozygous mutations of ABCB4 gene and her cirrhosis improved after treatment of ursodeoxycholic acid: a case report.Semantic proximity Read ↗

ABCB4 missense mutations D243A, K435T, G535D, I490T, R545C, and S978P significantly impair the lipid floppase and likely predispose to secondary pathologies in the human population.Semantic proximity Read ↗

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