Article

Phylogenetic Analysis of TET2 Gene Variants in Pakistani Acute Myeloid Leukemia Patients

2025-09-08

Abstract excerpt

<h4>Background</h4> Acute myeloid leukemia (AML) is a heterogeneous malignancy caused by the proliferation of neoplastic myeloid progenitor cells. Mutations in ten-eleven translocation methylcytosine dioxygenase 2 (TET2), a key regulator of DNA demethylation, are common in AML and play a role in its progression and response to treatment. <h4>Methods</h4> We performed a phylogenetic analysis of 25 TET2 gene seque...

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Literature Corpus work: a922802d-d7c3-5af5-9fa5-ade8bbd5c28c
DOI: 10.1101/2025.09.03.674098

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