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Article

Genetic Polymorphism Study of IDH 1/2 and TET2 Genes in Acute Myeloid leukemia Patients.

Asian Pacific journal of cancer prevention : APJCP - 1 Sept 2023

Atef Manal, Shafik Nevine Fawzy, H A Hassan Nagwa, Allam Rasha Mahmoud, El-Meligui Yomna Mohamed, Abdelaziz Hisham

Abstract excerpt

BACKGROUND AND OBJECTIVE: Isocitrate dehydrogenase genes (IDH1 and IDH2) encode important enzymes that play pivotal role in cellular metabolism. Mutations in TET2 have been demonstrated to contribute to DNA hypermethylation, either expression of mutant IDH1/2 or TET2 resulted in poor cell differentiation and epigenetic alterations in hematopoietic cells, suggesting a sharing of the oncogenetic impact. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37774069
DOI: 10.31557/APJCP.2023.24.9.3169
PMCID: PMC10762743

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