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Article

Chronic graft-versus-host-disease in CD34(+)-humanized NSG mice is associated with human susceptibility HLA haplotypes for autoimmune disease.

Journal of autoimmunity - 1 Aug 2015

Sonntag Katja, Eckert Franziska, Welker Christian, Müller Hartmut, Müller Friederike, Zips Daniel, Sipos Bence, Klein Reinhild, Blank Gregor, Feuchtinger Tobias, Schumm Michael, Handgretinger Rupert, Schilbach Karin

Abstract excerpt

Chronic graft-versus-host disease (cGVHD) is a significant hurdle to long-term hematopoietic stem-cell transplantation success. Insights into the pathogenesis and mechanistical investigations of novel therapeutic strategies are limited as appropriate animal models are missing. The immunodeficient NSG mouse - when humanized with human bone marrow, fetal liver and thymus (BLT NSG) - is prone for cGVHD, yet mainly...

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Identifiers

PMID: 26143958
DOI: 10.1016/j.jaut.2015.06.006

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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