Article

Dysregulation of the inside-out signaling pathway in CNS-infiltrated pediatric T-cell acute lymphoblastic leukemia

2026-07-05

Abstract excerpt

<title>Abstract</title> <p>A major obstacle to improving treatment efficacy and long-term survival in children with T-cell acute lymphoblastic leukemia (T-ALL) is the limited understanding of how leukemia cells infiltrate the central nervous system (CNS). By migrating to the CNS, leukemia cells can evade systemic therapy, contributing to disease progression and relapse. A better understanding of the mechanisms dr...

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Literature Corpus work: a8f2a714-6c36-5f09-8f52-501af3d42882
DOI: 10.21203/rs.3.rs-9944183/v1

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