Article

Reduced SK channel control of mesolimbic dopamine neuron firing drives reward seeking adaptations in chronic pain

2025-10-07

Abstract excerpt

Patients with chronic neuropathic pain typically experience affective symptoms that drive reduced quality of life and negatively impact pain management. Mesolimbic dopamine is necessary for reward valuation and learning, and the existence of a hypodopaminergic state has been proposed to underlie these affective symptoms of chronic pain. However, direct functional evidence for this hypodopaminergic state is lacking...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a8d0b24f-80c8-5576-b577-02c4314f3cb3
DOI: 10.1101/2025.10.06.680596

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reduced SK channel control of mesolimbic dopamine neuron firing drives reward seeking adaptations in chronic painDOI 10.1101/2025.10.06.680596Read

Molecular Identification of Pro-Excitogenic Receptor and Channel Phenotypes of the Deafferented Lumbar Motoneurons in the Early Phase after SCT in Rats.Semantic proximity Read

Ionic Mechanisms Underlying Bistability in Spinal Motoneurons: Insights from a Computational ModelSemantic proximity Read

SK channel function regulates the dopamine phenotype of neurons in the substantia nigra pars compacta.Semantic proximity Read

Ca <sup>2+</sup> -dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapsesSemantic proximity Read

Machine learning elucidates electrophysiological properties predictive of multi- and single-firing human and mouse dorsal root ganglia neuronsSemantic proximity Read

Altered potassium channel function in the superficial dorsal horn of the spastic mouse.Semantic proximity Read

Vagus nerve stimulation accelerates motor learning through cholinergic modulationSemantic proximity Read

Neuropathy following spinal nerve injury shares features with the irritable nociceptor phenotype: A back-translational study of oxcarbazepine.Semantic proximity Read

Chronic diazepam reveals excessive homeostatic gain in SOD1 <sup>G93A</sup> mouse spinal motoneuronsSemantic proximity Read

The Role of VTA Dopaminergic Neurons in Chronic Peripheral Neuropathic Pain- induced Depressive-like BehaviorSemantic proximity Read

Reduced high-frequency motor neuron firing, EMG fractionation, and gait variability in awake walking ALS mice.Semantic proximity Read

SYSTEM XC- AS A MOLECULAR MECHANISM FOR EVOLUTIONARY NEW FORMS OF ADVANCED COGNITIONSemantic proximity Read