Article
Neuropathy following spinal nerve injury shares features with the irritable nociceptor phenotype: A back-translational study of oxcarbazepine.
European journal of pain (London, England) - 1 Jan 2019
Patel Ryan, Kucharczyk Mateusz, Montagut-Bordas Carlota, Lockwood Stevie, Dickenson Anthony H
Abstract excerpt
BACKGROUND: The term 'irritable nociceptor' was coined to describe neuropathic patients characterized by evoked hypersensitivity and preservation of primary afferent fibres. Oxcarbazepine is largely ineffectual in an overall patient population, but has clear efficacy in a subgroup with the irritable nociceptor profile. We examine whether neuropathy in rats induced by spinal nerve injury shares overlapping...
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