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Article

Reduced high-frequency motor neuron firing, EMG fractionation, and gait variability in awake walking ALS mice.

Proceedings of the National Academy of Sciences of the United States of America - 22 Nov 2016

Hadzipasic Muhamed, Ni Weiming, Nagy Maria, Steenrod Natalie, McGinley Matthew J, Kaushal Adi, Thomas Eleanor, McCormick David A, Horwich Arthur L

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease prominently featuring motor neuron (MN) loss and paralysis. A recent study using whole-cell patch clamp recording of MNs in acute spinal cord slices from symptomatic adult ALS mice showed that the fastest firing MNs are preferentially lost. To measure the in vivo effects of such loss, awake symptomatic-stage ALS mice performing...

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Identifiers

PMID: 27821773
DOI: 10.1073/pnas.1616832113
PMCID: PMC5127366

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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