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Article

Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome.

Cell - 3 Feb 2022

Jin Wen-Bing, Li Ting-Ting, Huo Da, Qu Sophia, Li Xin V, Arifuzzaman Mohammad, Lima Svetlana F, Shi Hui-Qing, Wang Aolin, Putzel Gregory G, Longman Randy S, Artis David, Guo Chun-Jun

Abstract excerpt

Hundreds of microbiota genes are associated with host biology/disease. Unraveling the causal contribution of a microbiota gene to host biology remains difficult because many are encoded by nonmodel gut commensals and not genetically targetable. A general approach to identify their gene transfer methodology and build their gene manipulation tools would enable mechanistic dissections of their impact on host...

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Identifiers

PMID: 35051369
DOI: 10.1016/j.cell.2021.12.035
PMCID: PMC8919858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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