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Development of a Humanized Murine Model for the Study of Oxalobacter formigenes Intestinal Colonization

11 Jul 2019

Abstract excerpt

BACKGROUND: Oxalobacter formigenes are bacteria that colonize the human gut and degrade oxalate, a component of most kidney stones. Findings of clinical and epidemiological studies suggest that O. formigenes colonization reduces the risk for kidney stones. We sought to develop murine models to allow investigating O. formigenes in the context of its native human microbiome. METHODS: For humanization, we...

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PMID: 31328778
DOI: 10.1093/infdis/jiz370

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