Article

MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy

2023-01-12

Abstract excerpt

Misfolded protein aggregates may cause toxic proteinopathy, including autosomal dominant tubulointerstitial kidney disease due to uromodulin mutations (ADTKD- UMOD ), one of the leading hereditary kidney diseases, and Alzheimer’s disease etc. There are no targeted therapies. ADTKD is also a genetic form of renal fibrosis and chronic kidney disease, which affects 500 million people worldwide. For the first time, i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0301e13b-6773-5ce8-9da0-c75ab1125402
DOI: 10.1101/2023.01.10.523171

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathyDOI 10.1101/2023.01.10.523171Read

MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in miceSemantic proximity Read

MANF Clears Mutant Uromodulin in Human Kidney Organoids of Autosomal Dominant Tubulointerstitial Kidney DiseaseSemantic proximity Read

Mechanisms of protein toxicity in neurodegenerative diseasesSemantic proximity Read

The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in Caenorhabditis elegansSemantic proximity Read

NCBP2-AS2 is a mitochondrial microprotein, regulates energy metabolism and neurogenesis, and is downregulated in Alzheimer’s diseaseSemantic proximity Read

Chaperone-mediated autophagy degrades SERPINA1 E342K /α1-antitrypsin Z variant and alleviates cell stressSemantic proximity Read

Neuronopathic Gaucher disease: dysregulated mRNAs and miRNAs in brain pathogenesis and effects of pharmacologic chaperone treatment in a mouse model.Semantic proximity Read

Therapeutic targeting the cGAS−STING pathway associated with protein and gene: An emerging and promising novel strategy for aging-related neurodegenerative diseaseSemantic proximity Read

Calorie restriction leads to degradation of mutant uromodulin and ameliorates inflammation and fibrosis in <i>UMOD</i> -related kidney diseaseSemantic proximity Read

Calorie Restriction Leads to Degradation of Mutant Uromodulin and Ameliorates Inflammation and Fibrosis in UMOD -Related Kidney Disease.Semantic proximity Read

Allelic and Gene Dosage Effects Involving Uromodulin Aggregates Drive Autosomal Dominant Tubulointerstitial Kidney DiseaseSemantic proximity Read

Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy modelsSemantic proximity Read