Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

What Is the Role of Stathmin-2 in Axonal Biology and Degeneration?

16 Aug 2021

Abstract excerpt

Stathmin-2 (STMN2) is a microtubule-associated protein that has a major role in axonal development and repair. STMN2 promotes microtubule instability necessary for normal axonal outgrowth and regeneration. The expression of STMN2 is strongly regulated by nuclear transactive response DNA-binding protein 43 kDA (TDP-43). This multifunctional nucleic acid binding protein is a primary component of insoluble...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Genetic Neurodegenerative Diseases
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34400561
DOI: 10.1212/wnl.0000000000012419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

What Is the Role of Stathmin-2 in Axonal Biology and Degeneration?PMID 34400561Read ↗

Stathmins and Motor Neuron Diseases: Pathophysiology and Therapeutic TargetsSemantic proximity Read ↗

Stathmin-2: adding another piece to the puzzle of TDP-43 proteinopathies and neurodegenerationSemantic proximity Read ↗

Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervationSemantic proximity Read ↗

Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathySemantic proximity Read ↗

Reduced STMN2 and pathogenic TDP-43, two hallmarks of ALS, synergize to accelerate motor decline in miceSemantic proximity Read ↗

Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia.Semantic proximity Read ↗

Connecting TDP-43 Pathology with Neuropathy.Semantic proximity Read ↗

Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems.Semantic proximity Read ↗

Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy†Semantic proximity Read ↗

Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer’s diseaseSemantic proximity Read ↗

Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathiesSemantic proximity Read ↗

Matrin 3 in neuromuscular disease: physiology and pathophysiology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.