Article

Exploring the common genetic architecture of autism spectrum disorder using a novel multi-polygenic risk score approach

2023-05-28

Abstract excerpt

<h4>ABSTRACT</h4> Compared to disorders of similar heritability and contribution of common variants, few genome-wide significant loci have been implicated in autism spectrum disorder (ASD). This undermines the use of polygenic risk scores (PRSs) to investigate the common genetic architecture of ASD. Deconstructing PRS-ASD into its related traits via “developmental deconstruction” could reveal the underlying geneti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a89d3ce9-cdcb-5ce1-9e34-4861575be38a
DOI: 10.1101/2023.05.23.23290405

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exploring the common genetic architecture of autism spectrum disorder using a novel multi-polygenic risk score approachDOI 10.1101/2023.05.23.23290405Read

The Yin and Yang of Autism Genetics: How Rare De Novo and Common Variations Affect Liability.Semantic proximity Read

How rare and common risk variation jointly affect liability for autism spectrum disorder.Semantic proximity Read

Polygenic risk score and heritability estimates reveals a genetic relationship between ASD and OCD.Semantic proximity Read

Enhancing the Discriminatory Power of ADHD and Autism Spectrum Disorder Polygenic Scores in Clinical and Non-Clinical SamplesSemantic proximity Read

Characterizing genetic pathways unique to autism spectrum disorder at multiple levels of biological analysis.Semantic proximity Read

Deep embedded clustering by relevant scales and genome-wide association study in autismSemantic proximity Read

Characterizing Genetic Pathways Unique to Autism Spectrum Disorder at Multiple Levels of Biological AnalysisSemantic proximity Read

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups.Semantic proximity Read

A critical role of brain network architecture in a continuum model of autism spectrum disorders spanning from healthy individuals with genetic liability to individuals with ASDSemantic proximity Read

Deep embedded clustering by relevant scales and genome-wide association study in autismSemantic proximity Read

Estimation of Direct and Indirect Polygenic Effects and Gene-Environment Interactions using Polygenic Scores in Case-Parent Trio StudiesSemantic proximity Read

Estimation of direct and indirect polygenic effects and gene-environment interactions using polygenic scores in case-parent trio studies.Semantic proximity Read