Article
The Yin and Yang of Autism Genetics: How Rare De Novo and Common Variations Affect Liability.
Annual review of genomics and human genetics - 31 Aug 2017
Chaste Pauline, Roeder Kathryn, Devlin Bernie
Abstract excerpt
The etiology of autism spectrum disorder (ASD) is complex, involving both genetic and environmental contributions to individual and population-level liability. Early researchers hypothesized that ASD arises from polygenic inheritance, but later results, such as the identification of mutations in certain genes that are responsible for syndromes associated with ASD, led others to propose that de novo mutations of...
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