Polygenic risk score and heritability estimates reveals a genetic relationship between ASD and OCD.

doi:10.1016/j.euroneuro.2017.03.011

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Article

Polygenic risk score and heritability estimates reveals a genetic relationship between ASD and OCD.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jul 2017

Guo W, Samuels J F, Wang Y, Cao H, Ritter M, Nestadt P S, Krasnow J, Greenberg B D, Fyer A J, McCracken J T, Geller D A, Murphy D L, Knowles J A, Grados M A, Riddle M A, Rasmussen S A, McLaughlin N C, Nurmi E L, Askland K D, Cullen B A, Piacentini J, Pauls D L, Bienvenu O J, Stewart S E, Goes F S, Maher B, Pulver A E, Valle D, Mattheisen M, Qian J, Nestadt G, Shugart Y Y

Abstract excerpt

Obsessive-compulsive disorder (OCD) and Autism spectrum disorder (ASD) are both highly heritable neurodevelopmental disorders that conceivably share genetic risk factors. However, the underlying genetic determinants remain largely unknown. In this work, the authors describe a combined genome-wide association study (GWAS) of ASD and OCD. The OCD dataset includes 2998 individuals in nuclear families. The ASD...

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Identifiers

PMID: 28641744
DOI: 10.1016/j.euroneuro.2017.03.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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