Article
How rare and common risk variation jointly affect liability for autism spectrum disorder.
Molecular autism - 6 Oct 2021
Klei Lambertus, McClain Lora Lee, Mahjani Behrang, Panayidou Klea, De Rubeis Silvia, Grahnat Anna-Carin Säll, Karlsson Gun, Lu Yangyi, Melhem Nadine, Xu Xinyi, Reichenberg Abraham, Sandin Sven, Hultman Christina M, Buxbaum Joseph D, Roeder Kathryn, Devlin Bernie
Abstract excerpt
BACKGROUND: Genetic studies have implicated rare and common variations in liability for autism spectrum disorder (ASD). Of the discovered risk variants, those rare in the population invariably have large impact on liability, while common variants have small effects. Yet, collectively, common risk variants account for the majority of population-level variability. How these rare and common risk variants jointly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.