Article
Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups.
Nature genetics - 1 Oct 2022
Mattheisen Manuel, Grove Jakob, Als Thomas D, Martin Joanna, Voloudakis Georgios, Meier Sandra, Demontis Ditte, Bendl Jaroslav, Walters Raymond, Carey Caitlin E, Rosengren Anders, Strom Nora I, Hauberg Mads Engel, Zeng Biao, Hoffman Gabriel, Zhang Wen, Bybjerg-Grauholm Jonas, Bækvad-Hansen Marie, Agerbo Esben, Cormand Bru, Nordentoft Merete, Werge Thomas, Mors Ole, Hougaard David M, Buxbaum Joseph D, Faraone Stephen V, Franke Barbara, Dalsgaard Søren, Mortensen Preben B, Robinson Elise B, Roussos Panos, Neale Benjamin M, Daly Mark J, Børglum Anders D
Abstract excerpt
Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are highly heritable neurodevelopmental conditions, with considerable overlap in their genetic etiology. We dissected their shared and distinct genetic etiology by cross-disorder analyses of large datasets. We identified seven loci shared by the disorders and five loci differentiating them. All five differentiating loci showed...
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