Article

Transcriptomic-based quantification of the epithelial-hybrid-mesenchymal spectrum across biological contexts

2021-09-10

Abstract excerpt

Epithelial-mesenchymal plasticity (EMP) underlies embryonic development, wound healing, and cancer metastasis and fibrosis. Cancer cells exhibiting EMP often have more aggressive behavior, characterized by drug resistance, and tumor-initiating and immuno-evasive traits. Thus, the EMP status of cancer cells can be a critical indicator of patient prognosis. Here, we compare three distinct transcriptomic-based metric...

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Literature Corpus work: a87bc91b-2b42-5660-a9c3-b4ace0fbe24a
DOI: 10.1101/2021.09.09.458982

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