Article

Metformin Combined with Local Irradiation Provokes Abscopal Effects in a Murine Rectal Cancer Model

2021-12-28

Abstract excerpt

<h4>Background: </h4> Although preoperative chemoradiation therapy can down-stage locally advanced rectal cancer (LARC), it has little effect on distant metastases. Metformin exerts an anti-cancer effect partly through the activation of host immunity. <h4>Method: </h4> LuM1, a highly lung metastatic subclone of colon 26, was injected subcutaneously in BALB/c mice and treated with metformin and/or local radiation (...

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Literature Corpus work: a871ba70-fd41-56e5-8309-5de363d5ee50
DOI: 10.21203/rs.3.rs-1179271/v1

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