Article
Metformin inhibits the radiation-induced invasive phenotype of esophageal squamous cell carcinoma.
International journal of oncology - 1 Nov 2016
Nakayama Akira, Ninomiya Itasu, Harada Shinichi, Tsukada Tomoya, Okamoto Koichi, Nakanuma Shinichi, Sakai Seisho, Makino Isamu, Kinoshita Jun, Hayashi Hironori, Oyama Katsunobu, Miyashita Tomoharu, Tajima Hidehiro, Takamura Hiroyuki, Fushida Sachio, Ohta Tetsuo
Abstract excerpt
Esophageal cancer is one of the most aggressive tumor types because of its invasiveness and metastatic potential. Several reports have described an association between increased invasiveness after ionizing radiation (IR) treatment and epithelial-to-mesenchymal transition (EMT). The biguanide metformin is reported to prevent transforming growth factor-β (TGF-β)-induced EMT and proliferation of cancer. This study...
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