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Article

Radiation and SN38 treatments modulate the expression of microRNAs, cytokines and chemokines in colon cancer cells in a p53-directed manner.

Oncotarget - 29 Dec 2015

Pathak Surajit, Meng Wen-Jian, Nandy Suman Kumar, Ping Jie, Bisgin Atil, Helmfors Linda, Waldmann Patrik, Sun Xiao-Feng

Abstract excerpt

Aberrant expression of miRNAs, cytokines and chemokines are involved in pathogenesis of colon cancer. However, the expression of p53 mediated miRNAs, cyto- and chemokines after radiation and SN38 treatment in colon cancer remains elusive. Here, human colon cancer cells, HCT116 with wild-type, heterozygous and a functionally null p53, were treated by radiation and SN38. The expression of 384 miRNAs was determined...

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Identifiers

PMID: 26556872
DOI: 10.18632/oncotarget.5815
PMCID: PMC4792590

Genes

MIP
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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