Back to search

Article

A Mendelian randomization study with clinical follow-up links metabolites to risk and severity of pulmonary arterial hypertension

2023-07-01

Abstract excerpt

Pulmonary arterial hypertension (PAH) exhibits phenotypic heterogeneity and variable response to therapy. The metabolome has been implicated in the pathogenesis of PAH, but previous works have lacked power to implicate specific metabolites. Mendelian randomisation (MR) is a method for causal inference between exposures and outcomes. Using GWAS summary statistics, we implemented hypothesis-free MR methodology to te...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a8624f5d-029b-5aa8-8dba-48cd8df55040
DOI
10.1101/2023.06.30.23292100
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Mendelian randomization study with clinical follow-up links metabolites to risk and severity of pulmonary arterial hypertensionDOI 10.1101/2023.06.30.23292100
Mendelian Randomization Study With Clinical Follow‐Up Links Metabolites to Risk and Severity of Pulmonary Arterial HypertensionSemantic proximity
Metabolomic insights into pulmonary fibrosis: a mendelian randomization study.Semantic proximity
Assessment of causal associations among gut microbes,plasma metabolites and idiopathic pulmonary fibrosis: a bidirectional Mendelian randomization studySemantic proximity
Understanding pulmonary hypertension: the need for an integrative metabolomics and transcriptomics approachSemantic proximity
Exploring the Causal Relationship Between Gut Microbiota and Pulmonary Artery Hypertension: Insights From Mendelian RandomizationSemantic proximity
Mendelian Randomization revealed a one-way causal association between increased Isovalerylcarnitine (C5) levels and the risk of idiopathic pulmonary fibrosisSemantic proximity
Whole-Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical OutcomeSemantic proximity
Causal impact of gut microbiota and associated metabolites on pulmonary arterial hypertension: a bidirectional Mendelian randomization studySemantic proximity
Mendelian randomization linking metabolites with enzymes reveals known and novel pathway regulation and therapeutic avenuesSemantic proximity
Plasma metabolomics and scar pathogenesis: Insights from Mendelian randomization analysis.Semantic proximity
Mendelian randomization linking metabolites with enzymes reveals pathway regulation and therapeutic avenues.Semantic proximity
Mitochondrial dysfunction drives the pathogenesis of pulmonary arterial hypertension: insights from a multi-omics investigationSemantic proximity
Select a neighboring publication to make it the new centre.