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Article

Vitamin D Attenuates Fibrotic Properties of Fibrous Dysplasia-Derived Cells for the Transit towards Osteocytic Phenotype.

International journal of molecular sciences - 1 May 2024

Kim Ha-Young, Shim Jung-Hee, Kim Baek-Kyu, Heo Chan-Yeong

Abstract excerpt

Fibrous dysplasia (FD) poses a therapeutic challenge due to the dysregulated extracellular matrix (ECM) accumulation within affected bone tissues. In this study, we investigate the therapeutic potential of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in managing FD by examining its effects on FD-derived cells in vitro. Our findings demonstrate that 1,25(OH)2D3 treatment attenuates the pro-fibrotic phenotype of...

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Identifiers

PMID: 38732172
DOI: 10.3390/ijms25094954
PMCID: PMC11084186

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