Article

BMI-1 activates hepatic stellate cells to promote EMT of colorectal cancer cells

2022-12-13

Abstract excerpt

Activated hepatic stellate cells (aHSCs) are the major source of cancer-associated fibroblasts (CAFs) in the liver. Though the crosstalk between aHSCs and colorectal cancer (CRC) cells supports liver metastasis (LM), the mechanisms remain largely unknown. Here, we investigated BMI-1, a polycomb-group protein family member, which is high-expressed in LM, in hepatic stellate cells (HSCs) activation and interacting w...

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Literature Corpus work: a85df60c-0e77-5ab4-bf11-0e48cee86232
DOI: 10.21203/rs.3.rs-2247681/v1

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