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Article

Hepatic stellate cells secreted hepatocyte growth factor contributes to the chemoresistance of hepatocellular carcinoma.

PloS one - 1 Jan 2013

Yu Guofeng, Jing Yingying, Kou Xingrui, Ye Fei, Gao Lu, Fan Qingmin, Yang Yang, Zhao Qiudong, Li Rong, Wu Mengchao, Wei Lixin

Abstract excerpt

As the main source of extracellular matrix proteins in tumor stroma, hepatic stellate cells (HSCs) have a great impact on biological behaviors of hepatocellular carcinoma (HCC). In the present study, we have investigated a mechanism whereby HSCs modulate the chemoresistance of hepatoma cells. We used human HSC line lx-2 and chemotherapeutic agent cisplatin to investigate their effects on human HCC cell line...

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Identifiers

PMID: 24023859
DOI: 10.1371/journal.pone.0073312
PMCID: PMC3759390

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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