Article

Coffee remodels the global histone acetylation landscape with reduced H3K27ac at the <i>MYC</i> promoter

2026-08-03

Abstract excerpt

Coffee consumption has been associated with reduced risks of multiple chronic diseases, including cancer; however, whether coffee regulates the epigenetic landscape remains largely unknown. Here, we show that coffee extensively remodels the histone acetylation landscape in human cells. Quantitative histone modification proteomics revealed a global reduction in active histone acetylation marks following coffee trea...

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Literature Corpus work: a853621e-0b98-5ca4-8758-b7396d82abb0
DOI: 10.64898/2026.08.01.742200

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