Article

Formaldehyde Exposure Induces Systemic Epigenetic Alterations in Histone Methylation and Acetylation

2025-03-01

Abstract excerpt

Formaldehyde (FA) is a pervasive environmental organic pollutant and a Group 1 human carcinogen. While FA has been implicated in various cancers, its genotoxic effects, including DNA damage and DNA-protein crosslinking, have proven insufficient to fully explain its role in carcinogenesis, suggesting the involvement of epigenetic mechanisms. Histone post-translational modifications (PTMs) on H3 and H4, critical for...

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Literature Corpus work: 97052fd0-9f31-57c8-9ab0-d07cfe6b4cba
DOI: 10.1101/2025.02.25.640236

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