Article

Multiplexed biochemical imaging reveals the extent and complexity of non-genetic heterogeneity in DNA damage-induced caspase dynamics

2018-01-01

Abstract excerpt

Genetically identical cells show a heterogeneous response to a multitude of signals such as growth factors and DNA damage. While this heterogeneity has been shown to be a major determinant of treatment success in several diseases including cancer, little is known about how differences in biochemical signalling networks underlie such heterogeneity. State-of-the-art methodologies to study biochemical networks are of...

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Literature Corpus work: a83fa4a3-e887-59f6-8f7b-dd5f10807421
DOI: 10.17863/cam.20943

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