Article

Assessing PARP trapping dynamics in ovarian cancer using a CRISPR-engineered FRET biosensor

2025-03-14

Abstract excerpt

Poly(ADP-ribose) polymerase inhibitors (PARPi) have revolutionised the treatment of ovarian high grade serous carcinoma (HGSC), especially those with defective homologous recombination. However, the emergence of resistance poses a critical challenge, as over 50% of patients relapse within three years. The mechanisms underlying changes in PARP trapping, a central aspect of PARPi efficacy, are not well understood du...

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Literature Corpus work: 4e249aa5-61d4-5cc7-96d8-4e5e2bb9d35c
DOI: 10.1101/2025.03.12.642798

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